Terra Das Araras Vermelhas Pdf Download ackehary
Terra das araras – Carlos Pellegrino L. (Editor) Lê, N. L. Cidade, meio e Terra. Proporções geométricas, distribuição espacial e urbanização de Vila do Maçã e Ibiúna, 1872–1922. São Paulo: Editora Atlas, 2011. Category:Alterra familyAnnexin A2-mediated signaling is linked to Ca2+-dependent exocytosis in Drosophila melanogaster salivary gland cells. The paraneoplastic autoantibody 12E7 is an autoantigen of the nervous system that binds to a neuronal-secreted protein, the antigen was shown to be a member of the annexin family, annexin A2. The 12E7 epitope is also detected in the salivary gland cells of Drosophila melanogaster, however the physiological function of annexin A2 in this cell type is not understood. Previous work demonstrated that annexin A2 has a physiological role in late pupal-adult ecdysis in Drosophila melanogaster. We have carried out a detailed analysis of the expression, subcellular localization and function of annexin A2 in Drosophila salivary gland cells. The level of annexin A2 protein was comparable in both early pupal and adult salivary glands. Interestingly, the expression of annexin A2 in the developing salivary gland correlated with the induction of Ca2+-dependent exocytosis. Moreover, using affinity chromatography, we show that purified 12E7 protein binds to an N-terminal sequence of annexin A2. The present study provides evidence that annexin A2 is involved in Ca2+-dependent exocytosis in salivary glands. We propose that an early pupal annexin A2-mediated signal is transmitted to the late pupal-adult ecdysis.